D12451 Research diet 2.5HS 45% KCAL fat

Research Diets

31797

  • 45 kcal% fat purified DIO diet (~4.73 kcal/g) for rodents
  • Casein-based formula with lard as primary fat source
  • Sucrose-matched control: D12450H. ~General control: D12450B

FAQ - D12451 Research diet 2.5HS 45% KCAL fat

When is D12451 chosen over D12492?

D12451 provides 45 kcal% fat and is used when a moderate high-fat challenge is preferred to the 60 kcal% fat profile of D12492.

Which control diet is matched to D12451?

D12450H matches the sucrose calories of D12451, allowing equal sucrose intake between low-fat and high-fat groups consuming equal calories.

Which species is D12451 suitable for?

D12451 is formulated for laboratory rats and mice in DIO and metabolic research.

Product Instructions

Feed ad libitum in DIO protocols, according to facility guidelines and study design.

D12451 is a purified high-fat diet from Research Diets that provides 45 kcal% fat for diet-induced obesity and other metabolic research in rats and mice. Macronutrient distribution is 45 kcal% fat, 20 kcal% protein and 35 kcal% carbohydrate, with an energy density of approximately 4.73 kcal/g. D12451 is part of the Research Diets DIO (Diet-Induced Obesity) series and represents the moderately high-fat reference within that family of matched formulas.

Formulation

  • Defined-ingredient purified formula with casein as the protein source.
  • Fat fraction supplied primarily by lard with soybean oil.
  • Carbohydrate fraction from corn starch, maltodextrin 10 and sucrose.
  • Color-coded red for visual distinction in study designs.

Use in DIO models

D12451 is the established 45 kcal% fat reference diet in the Research Diets DIO series, applied where a moderately high-fat challenge is preferred over the 60 kcal% fat D12492. The matched sucrose-aligned control is D12450H, while D12450B serves as the original general low-fat reference.

Standard delivery is in cases of 12.5 kg, divided into 2.5 kg heat sealed foil bags. The diet can be modified on request and is also available irradiated. Contact our specialists for advice at researchdiets@brogaarden.eu.

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